Rapamycin increases rDNA stability by enhancing association of Sir2 with rDNA in Saccharomyces cerevisiae.
Identifieur interne : 001271 ( Main/Exploration ); précédent : 001270; suivant : 001272Rapamycin increases rDNA stability by enhancing association of Sir2 with rDNA in Saccharomyces cerevisiae.
Auteurs : Cheol Woong Ha [Corée du Sud] ; Won-Ki HuhSource :
- Nucleic acids research [ 1362-4962 ] ; 2011.
Descripteurs français
- KwdFr :
- ADN ribosomique (métabolisme), Acétylation (MeSH), Azote (métabolisme), Extinction de l'expression des gènes (MeSH), Histone (métabolisme), Nicotinamidase (métabolisme), Nucléole (effets des médicaments et des substances chimiques), Nucléole (ultrastructure), Phosphatidylinositol 3-kinases (métabolisme), Protéines SIR de Saccharomyces cerevisiae (métabolisme), Protéines de Saccharomyces cerevisiae (antagonistes et inhibiteurs), Protéines de Saccharomyces cerevisiae (métabolisme), Protéines de Saccharomyces cerevisiae (physiologie), Protéines du cycle cellulaire (physiologie), Protéines nucléaires (physiologie), Saccharomyces cerevisiae (effets des médicaments et des substances chimiques), Saccharomyces cerevisiae (génétique), Saccharomyces cerevisiae (métabolisme), Sirolimus (pharmacologie), Sirtuine-2 (métabolisme), Transduction du signal (MeSH).
- MESH :
- antagonistes et inhibiteurs : Protéines de Saccharomyces cerevisiae.
- effets des médicaments et des substances chimiques : Nucléole, Saccharomyces cerevisiae.
- génétique : Saccharomyces cerevisiae.
- métabolisme : ADN ribosomique, Azote, Histone, Nicotinamidase, Phosphatidylinositol 3-kinases, Protéines SIR de Saccharomyces cerevisiae, Protéines de Saccharomyces cerevisiae, Saccharomyces cerevisiae, Sirtuine-2.
- pharmacologie : Sirolimus.
- physiologie : Protéines de Saccharomyces cerevisiae, Protéines du cycle cellulaire, Protéines nucléaires.
- ultrastructure : Acétylation, Extinction de l'expression des gènes, Nucléole, Transduction du signal.
English descriptors
- KwdEn :
- Acetylation (MeSH), Cell Cycle Proteins (physiology), Cell Nucleolus (drug effects), Cell Nucleolus (ultrastructure), DNA, Ribosomal (metabolism), Gene Silencing (MeSH), Histones (metabolism), Nicotinamidase (metabolism), Nitrogen (metabolism), Nuclear Proteins (physiology), Phosphatidylinositol 3-Kinases (metabolism), Phosphoinositide-3 Kinase Inhibitors (MeSH), Saccharomyces cerevisiae (drug effects), Saccharomyces cerevisiae (genetics), Saccharomyces cerevisiae (metabolism), Saccharomyces cerevisiae Proteins (antagonists & inhibitors), Saccharomyces cerevisiae Proteins (metabolism), Saccharomyces cerevisiae Proteins (physiology), Signal Transduction (MeSH), Silent Information Regulator Proteins, Saccharomyces cerevisiae (metabolism), Sirolimus (pharmacology), Sirtuin 2 (metabolism).
- MESH :
- chemical , antagonists & inhibitors : Saccharomyces cerevisiae Proteins.
- chemical , metabolism : DNA, Ribosomal, Histones, Nicotinamidase, Nitrogen, Saccharomyces cerevisiae Proteins, Silent Information Regulator Proteins, Saccharomyces cerevisiae, Sirtuin 2.
- chemical , pharmacology : Sirolimus.
- chemical , physiology : Cell Cycle Proteins, Nuclear Proteins, Saccharomyces cerevisiae Proteins.
- drug effects : Cell Nucleolus, Saccharomyces cerevisiae.
- genetics : Saccharomyces cerevisiae.
- metabolism : Phosphatidylinositol 3-Kinases, Saccharomyces cerevisiae.
- ultrastructure : Cell Nucleolus.
- Acetylation, Gene Silencing, Phosphoinositide-3 Kinase Inhibitors, Signal Transduction.
Abstract
The target of rapamycin (TOR) kinase is an evolutionarily conserved key regulator of eukaryotic cell growth and proliferation. Recently, it has been reported that inhibition of TOR signaling pathway can delay aging and extend lifespan in several eukaryotic organisms, but how lifespan extension is mediated by inhibition of TOR signaling is poorly understood. Here we report that rapamycin treatment and nitrogen starvation, both of which cause inactivation of TOR complex 1 (TORC1), lead to enhanced association of Sir2 with ribosomal DNA (rDNA) in Saccharomyces cerevisiae. TORC1 inhibition increases transcriptional silencing of RNA polymerase II-transcribed gene integrated at the rDNA locus and reduces homologous recombination between rDNA repeats that causes formation of toxic extrachromosomal rDNA circles. In addition, TORC1 inhibition induces deacetylation of histones at rDNA. We also found that Pnc1 and Net1 are required for enhancement of association of Sir2 with rDNA under TORC1 inhibition. Taken together, our findings suggest that inhibition of TORC1 signaling stabilizes the rDNA locus by enhancing association of Sir2 with rDNA, thereby leading to extension of replicative lifespan in S. cerevisiae.
DOI: 10.1093/nar/gkq895
PubMed: 20947565
PubMed Central: PMC3045593
Affiliations:
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3-Kinases</term><term>Saccharomyces cerevisiae</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>ADN ribosomique</term><term>Azote</term><term>Histone</term><term>Nicotinamidase</term><term>Phosphatidylinositol 3-kinases</term><term>Protéines SIR de Saccharomyces cerevisiae</term><term>Protéines de Saccharomyces cerevisiae</term><term>Saccharomyces cerevisiae</term><term>Sirtuine-2</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Sirolimus</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Protéines de Saccharomyces cerevisiae</term><term>Protéines du cycle cellulaire</term><term>Protéines nucléaires</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Cell Nucleolus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Acetylation</term><term>Gene Silencing</term><term>Phosphoinositide-3 Kinase Inhibitors</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="fr"><term>Acétylation</term><term>Extinction de l'expression des gènes</term><term>Nucléole</term><term>Transduction du signal</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The target of rapamycin (TOR) kinase is an evolutionarily conserved key regulator of eukaryotic cell growth and proliferation. Recently, it has been reported that inhibition of TOR signaling pathway can delay aging and extend lifespan in several eukaryotic organisms, but how lifespan extension is mediated by inhibition of TOR signaling is poorly understood. Here we report that rapamycin treatment and nitrogen starvation, both of which cause inactivation of TOR complex 1 (TORC1), lead to enhanced association of Sir2 with ribosomal DNA (rDNA) in Saccharomyces cerevisiae. TORC1 inhibition increases transcriptional silencing of RNA polymerase II-transcribed gene integrated at the rDNA locus and reduces homologous recombination between rDNA repeats that causes formation of toxic extrachromosomal rDNA circles. In addition, TORC1 inhibition induces deacetylation of histones at rDNA. We also found that Pnc1 and Net1 are required for enhancement of association of Sir2 with rDNA under TORC1 inhibition. Taken together, our findings suggest that inhibition of TORC1 signaling stabilizes the rDNA locus by enhancing association of Sir2 with rDNA, thereby leading to extension of replicative lifespan in S. cerevisiae.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">20947565</PMID><DateCompleted><Year>2011</Year><Month>05</Month><Day>12</Day></DateCompleted><DateRevised><Year>2019</Year><Month>12</Month><Day>10</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1362-4962</ISSN><JournalIssue CitedMedium="Internet"><Volume>39</Volume><Issue>4</Issue><PubDate><Year>2011</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Nucleic acids research</Title><ISOAbbreviation>Nucleic Acids Res</ISOAbbreviation></Journal><ArticleTitle>Rapamycin increases rDNA stability by enhancing association of Sir2 with rDNA in Saccharomyces cerevisiae.</ArticleTitle><Pagination><MedlinePgn>1336-50</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/nar/gkq895</ELocationID><Abstract><AbstractText>The target of rapamycin (TOR) kinase is an evolutionarily conserved key regulator of eukaryotic cell growth and proliferation. Recently, it has been reported that inhibition of TOR signaling pathway can delay aging and extend lifespan in several eukaryotic organisms, but how lifespan extension is mediated by inhibition of TOR signaling is poorly understood. Here we report that rapamycin treatment and nitrogen starvation, both of which cause inactivation of TOR complex 1 (TORC1), lead to enhanced association of Sir2 with ribosomal DNA (rDNA) in Saccharomyces cerevisiae. TORC1 inhibition increases transcriptional silencing of RNA polymerase II-transcribed gene integrated at the rDNA locus and reduces homologous recombination between rDNA repeats that causes formation of toxic extrachromosomal rDNA circles. In addition, TORC1 inhibition induces deacetylation of histones at rDNA. We also found that Pnc1 and Net1 are required for enhancement of association of Sir2 with rDNA under TORC1 inhibition. Taken together, our findings suggest that inhibition of TORC1 signaling stabilizes the rDNA locus by enhancing association of Sir2 with rDNA, thereby leading to extension of replicative lifespan in S. cerevisiae.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ha</LastName><ForeName>Cheol Woong</ForeName><Initials>CW</Initials><AffiliationInfo><Affiliation>School of Biological Sciences, Research Center for Functional Cellulomics, Institute of Microbiology, Seoul National University, Seoul 151-747, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huh</LastName><ForeName>Won-Ki</ForeName><Initials>WK</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate 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IdType="pubmed">12297502</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Corée du Sud</li></country><region><li>Région capitale de Séoul</li></region><settlement><li>Séoul</li></settlement><orgName><li>Université nationale de Séoul</li></orgName></list><tree><noCountry><name sortKey="Huh, Won Ki" sort="Huh, Won Ki" uniqKey="Huh W" first="Won-Ki" last="Huh">Won-Ki Huh</name></noCountry><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Ha, Cheol Woong" sort="Ha, Cheol Woong" uniqKey="Ha C" first="Cheol Woong" last="Ha">Cheol Woong Ha</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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